Our interest with the niche started with our studies on tumor-stroma interactions. 

     Now we are trying to understand the interactions between the hematopoietic stem cells and their niche in the bone marrow. One of our main goals is to identify the distinct cell types that constitute specific hematopoietic niches and clarify how they regulate HSC fate decisions. We are focusing on endothelial cells which are in direct contact with HSC in the bone marrow.

     Thanks to the grant from DKMS Foundation we are also developing the new method to mobilize HSC and granulocytes from the bone marrow to the blood. 

HEMATOPOIETIC
STEM CELLS
AND THEIR NICHE

>>> TEAM MEMBERS

>>> CURRENT PROJECTS

Group Leader

Agata Szade

agata.szade@uj.edu.pl

PhD Student

Anna Kusienicka

anna.kusienicka@doctoral.uj.edu.pl 

Undergrad Students

Telli Mirzayeva

Mahdi Mahdi
 

Kinga Mależyna

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  • Hematopoietic stem cells and their niche - the role of endothelial cells.

  • Role of heme oxygenase-1 in tumor development and the interaction with tumor microenvironment. 

>>> OUR ACHIEVEMENTS

>>> OUR METHODS

  • Discovery of mobilizing properties
    of cobalt protoporphyrin IX (CoPP).

  • Flow cytometry and cell sorting.

  • Fluorescent imaging.

  • Tumor spheroid model.

  • Spectra viewers

  • How to choose fluorochromes

  • IHC protocols

  • Online courses

  • Bibliography management

  • Czarny Instagram Ikona

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