Our interest with the niche started when we were studying the tumor-stroma interactions. 

     Now we are trying to understand the interactions between the hematopoietic stem cells (and other blood cells) with their niche in the bone marrow. Our main research focus is the process of the mobilization of cells from the bone marrow to the blood.         

     With the support from the National Science Centre (NCN) we are trying to decipher the cellular and molecular mechanisms driving the induction of mobilizing cytokines. Thanks to the grants from DKMS Foundation and National Centre for Research and Development (NCBR) we are also developing the new method to mobilize HSC and granulocytes from the bone marrow to the blood. 

          So to put it simply- we are trying to learn how to get HSC out of their niche. 

HEMATOPOIETIC
STEM CELLS
AND THEIR NICHE

>>> TEAM MEMBERS

>>> CURRENT PROJECTS

Group Leader
Agata Szade
agata.szade@uj.edu.pl

 
Postdoc
Aleksandra Bednarz

 
Undergrad Students 
Kinga Mależyna
Wiktoria Białończyk
Iga Czechowska


Research Assistant
Paweł Kożuch


Intern
Raquel Garcia

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>>> OUR ACHIEVEMENTS

>>> OUR METHODS

  • Discovery of mobilizing properties
    of cobalt protoporphyrin IX (CoPP).

  • Flow cytometry and cell sorting.

  • Fluorescent imaging.

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