Our interest with the niche started with our studies on tumor-stroma interactions.
Now we are trying to understand the interactions between the hematopoietic stem cells and their niche in the bone marrow. One of our main goals is to identify the distinct cell types that constitute specific hematopoietic niches and clarify how they regulate HSC fate decisions. We are focusing on endothelial cells which are in direct contact with HSC in the bone marrow.
Thanks to the grant from DKMS Foundation we are also developing the new method to mobilize HSC and granulocytes from the bone marrow to the blood.
AND THEIR NICHE
>>> TEAM MEMBERS
>>> CURRENT PROJECTS
Hematopoietic stem cells and their niche - the role of endothelial cells.
Role of heme oxygenase-1 in tumor development and the interaction with tumor microenvironment.
>>> OUR ACHIEVEMENTS
>>> OUR METHODS
Discovery of mobilizing properties
of cobalt protoporphyrin IX (CoPP).
Flow cytometry and cell sorting.
Tumor spheroid model.