Our interest with the niche started when we were studying the tumor-stroma interactions.
Now we are trying to understand the interactions between the hematopoietic stem cells (and other blood cells) with their niche in the bone marrow. Our main research focus is the process of the mobilization of cells from the bone marrow to the blood.
With the support from the National Science Centre (NCN) we are trying to decipher the cellular and molecular mechanisms driving the induction of mobilizing cytokines. Thanks to the grants from DKMS Foundation and National Centre for Research and Development (NCBR) we are also developing the new method to mobilize HSC and granulocytes from the bone marrow to the blood.
So to put it simply- we are trying to learn how to get HSC out of their niche.
AND THEIR NICHE
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>>> CURRENT PROJECTS
A. Szade, K. Szade, M. Mahdi, A. Józkowicz: The role of heme oxygenase-1 in hematopoietic system and its microenvironment, Cell Mol Life Sci. 2021 Mar 31; Review.
K. Brulois*, A. Rajaraman*, A. Szade*, S. Nordling*, A. Bogoslowski, D. Dermadi, M. Rahman, H. Kiefel, E. O’Hara, J. J Koning, H. Kawashima, B. Zhou, D. Vestweber, K. Red-Horse, R. Mebius, RH. Adams, P. Kubes, J. Pan, EC. Butcher: A molecular map of murine lymph node blood vascular endothelium at single cell resolution, Nat Commun. 2020 Jul 30;11(1):3798.
A. Szade, K. Szade, WN. Nowak, K. Bukowska-Strakova, L. Muchova, M. Gonka, M. Żukowska, M. Cieśla, N. Kachamakova-Trojanowska, M. Rams-Baron, A. Ratuszna, J. Dulak, A. Józkowicz: Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes hematopoietic stem cells and granulocytes to the blood, EMBO Mol Med, 2019: e09571.
A. Szade, A. Grochot-Przęczek, U. Florczyk, A. Józkowicz, J. Dulak: Cellular and molecular mechanisms of inflammation-induced angiogenesis, IUBMB Life, 2015 Mar;67(3):145-59; Review.
K. Bukowska-Strakova, M. Ciesla, K. Szade, WN. Nowak, R. Straka, A. Szade, M. Tyszka-Czochara, K. Najder, A. Konturek, M. Siedlar, J. Dula, A. Jozkowicz: Heme oxygenase 1 affects granulopoiesis in mice through control of myelocyte proliferation, Immunobiology 2017, Jun;222(6):846-857.
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