AGING AND BIOLOGY
OF ENDOTHELIAL CELLS
Our goal is to identify the molecular mechanisms, which drive the premature senescence of endothelial cells and to determine the intracellular molecule switching between the senescent and apoptotic fate. The studies are focused on Nrf2/Keap1 system, protein S-nitrosation and miRNA-34a.
>>> TEAM MEMBERS
>>> CURRENT PROJECTS
Group Leader
Anna Grochot-Przęczek
anna.grochot-przeczek@uj.edu.pl
PhD Students
Damian Klóska
Aleksandra Kopacz
Undergrad Students
Maria Rostworowska
Piotr Świerzewski
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Senescence or apoptosis – the role of miR-34a in endothelial cells.
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Regulation of endothelial cell function by protein S-nitrosation and Keap1
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Transgenic mice models (cell-specific and total knockouts)
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Human primary endothelial cells derived from young and aged donors
>>> OUR ACHIEVEMENTS
>>> EXPERIMENTAL MODELS
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Endothelial cell fate is determined by Keap-1-dependent protein S-nitrosation
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Keap1/NOS/GAPDH is an enzymatic complex for S-nitrosation in mammals
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Nrf2 is an inhibitor of the Keap1 activity
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Nrf2 regulates angiogenesis independent of its transcriptional activity
>>> COOPERATION
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Dr. Marta Targosz-Korecka
Institute of Physics, Jagiellonian
University
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Dr. Bartosz Proniewski
Jagiellonian Centre for Experimental
Therapeutics
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Dr. Dominik Cysewski
Institute of Biochemistry and
Biophysics, Polish Academy of Science
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Dr. Henry Jay Forman
University of Southern California