AGING AND BIOLOGY
OF ENDOTHELIAL CELLS

  Our goal is to identify the molecular mechanisms, which drive the premature senescence of endothelial cells and to determine the intracellular molecule switching between the senescent and apoptotic fate. The studies are focused on Nrf2/Keap1 system, protein S-nitrosation and miRNA-34a.

>>> TEAM MEMBERS

>>> CURRENT PROJECTS

Group Leader

Anna Grochot-Przęczek 

anna.grochot-przeczek@uj.edu.pl 

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PhD Students

Damian Klóska

Aleksandra Kopacz

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Undergrad Students

Maria Rostworowska

Piotr Świerzewski

  • Senescence or apoptosis – the role of miR-34a in endothelial cells.

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  • Regulation of endothelial cell function by protein S-nitrosation and Keap1​

  • Transgenic mice models (cell-specific and total knockouts)

   

  • Human primary endothelial cells derived from young and aged donors

>>> OUR ACHIEVEMENTS

>>> EXPERIMENTAL MODELS

  • Endothelial cell fate is determined by Keap-1-dependent protein S-nitrosation​

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  • Keap1/NOS/GAPDH is an enzymatic complex for S-nitrosation in mammals

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  • Nrf2 is an inhibitor of the Keap1 activity

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  • Nrf2 regulates angiogenesis independent of its transcriptional activity

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>>> COOPERATION

  • Dr. Marta Targosz-Korecka

       ​Institute of Physics, Jagiellonian   

       University

  • Dr. Bartosz Proniewski

       Jagiellonian Centre for Experimental 

       Therapeutics

  • Dr. Dominik Cysewski

       ​Institute of Biochemistry and 

       Biophysics, Polish Academy of Science

  • Dr. Henry Jay Forman

       ​University of Southern California