INFLAMMATORY BOWEL DISEASES
AND THEIR ETIOLOGY
Although being thoroughly studied within the last few decades, the causes of inflammatory bowel diseases (IBD) are not fully elucidated. Yet we know that among the symptoms is intestinal fibrosis that may end up with intestinal obstruction. Fibrosis is associated with improper production of extracellular matrix components, mainly collagen, and fibronectin. Moreover, several cytokines have been shown to exert a pro-fibrogenic action in IBD. Pro-inflammatory cytokines may also disrupt redox homeostasis leading to oxidative stress, DNA damage, and premature senescence.
Our group aims to investigate the causes of fibrosis and cellular senescence in vivo and in vitro, which may have an important diagnostic and therapeutic potential.
>>> TEAM MEMBERS
>>> CURRENT PROJECTS
Group Leader
Aleksandra
Piechota-Polańczyk
aleksandra.piechota-polanczyk@uj.edu.pl
PhD Students
we are recruiting!
Former
undergrad students
Sylwia Nesterak
Jakub Limanówka
Daniel Bogucki
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Fibrosis or senescence - why lack of transcriptionally active Nrf2 protects against colon dysfunction
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Heme oxygenase in the development and progression of abdominal aortic aneurysm
>>> COOPERATION
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Prof. Christoph Neumayer - Department of Surgery, Division of Vascular Surgery, Medical University of Vienna, Austria.
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Prof. Christine Brostjan - Division of Vascular Surgery and Surgical Research Laboratories, Department of Surgery, Medical University of Vienna, Vienna General Hospital, Vienna, Austria
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Prof. Ihor Huk - Department of Surgery, Division of Vascular Surgery, Medical University of Vienna, Austria
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Prof. Jakub Fichna - Department of Biochemistry, Faculty of Medicine, Medical University of Łódz
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Prof. Agnieszka Piastowska -Ciesielska - Laboratory of Cell Cultures and Genomic Analysis, Medical University of Łódz
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Dr Agnieszka Jabłońska - Laboratory of Cell Cultures and Genomic Analysis, Department of Comparative Endocrinology, Medical University of Łódz
>>> FOUNDING
Fibrosis or senescence - why lack of transcriptionally active Nrf2 protects against colon dysfunction, Sonata program, National Science Centre, to be completed in 2022