Selected publications

Brulois K*, Rajaraman A*, Szade A*, Nordling S*, Bogoslowski A, Dermadi D, Rahman M, Kiefel H, O’Hara E, Koning JJ, Kawashima H, Zhou B, Vestweber D, Red-Horse K, Mebius RE, Adams RH, Kubes P, Pan J, Butcher EC A molecular map of murine lymph node blood vascular endothelium at single cell resolution Nat Commun 2020 Jul 30;11:3798. doi: 10.1038/s41467-020-17291-5

Kopacz A, Kloska D, Forman HJ, Jozkowicz A, Grochot-Przeczek A. Beyond repression of Nrf2: An update on Keap1. Free Radic Biol Med. 2020; pii: S0891-5849(19)32525-0

Targosz-Korecka M, Malek-Zietek KE, Kloska D, Rajfur Z, Stepien EŁ, Grochot-Przeczek A, Szymonski M. Metformin attenuates adhesion between cancer and endothelial cells in chronic hyperglycemia by recovery of the endothelial glycocalyx barrier. Biochim Biophys Acta Gen Subj, 2020; 1864(4):129533

Kopacz A., Kloska D., Proniewski B., Cysewski D., Personnic N., Piechota-Polanczyk A., Kaczara P., Zakrzewska A., Forman H.J., Dulak J., Jozkowicz A., Grochot-Przeczek A. Keap1 controls protein S-nitrosation
and apoptosis-senescence switch in endothelial cells.
Redox Biol, 2020, 28:101304

Gulati GS, Zukowska M, Noh JJ, Zhang A, Wesche DJ, Sinha R, George BM, Weissman IL, Szade K.
Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5 + mouse long-term hematopoietic stem cells. PNAS 2019: 116 (50) 25115-25125 i

Kloska D., Kopacz A., Piechota-Polanczyk A., Neumayer C., Huk I., Dulak J., Jozkowicz A., Grochot-Przeczek A. Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells. Arch Biochem Biophys, 2019, 678:108182

Rozga P., Kloska D., Pawlak S., Teska-Kaminska M., Galazka M., Bukato K., Pieczykolan A., Jaworski A, Molga A., Kopacz A., Badyra B., Kachamakova-Trojanowska N., Zolnierkiewicz O., Targosz-Korecka M., Poleszak K.,
Szymanik M., Zerek B., Pieczykolan J., Jozkowicz A., Grochot-Przeczek A. Novel engineered TRAIL-based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance. Int J Cancer, 2019, doi: 10.1002/ijc.32845

Szade A., Szade K., Nowak W.N., Bukowska-Strakova K., Muchova L., Gońka M., Żukowska M., Cieśla M., Kachamakova-Trojanowska N., Rams-Baron M., Ratuszna A., Dulak J., Józkowicz A. Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes hematopoietic stem cells and granulocytes to the blood.  EMBO Mol Med, 2019: e09571.

Nowak W.N., Taha H., Markiewicz J., Kachamakova-Trojanowska N., Stępniewski J., Klóska D., Florczyk-Soluch U., Niżankowski R., Frołow M., Walter Z., Dulak J., Józkowicz A. Atorvastatin enhances the paracrine proangiogenic activity of hematopoietic stem/progenitor-derived cells in vitro but not in vivo. Mediat Inflammat, 2019: 1868170.

Bednarz A., Lipiński P., Starzyński R., Tomczyk M., Nowak W., Mucha O., Ogórek M., Pierzchała O., Jończy A., Staroń R., Śmierzchalska J., Rajfur Z., Baster Z., Józkowicz A., Lenartowicz M. Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice. Sci Rep, 2019, 9: 11102.

Kloska D., Kopacz A., Cysewski D., Aepfelbacher M, Dulak J., Jozkowicz A., Grochot-Przeczek A. Nrf2 sequesters Keap1 preventing podosome disassembly: a quintessential duet moonlights in endothelium. Antioxid Redox Signal, 2019, 30: 1709-1730.

Kloska D., Kopacz A., Piechota-Polanczyk A., Nowak W., Dulak J., Jozkowicz A., Grochot-Przeczek A. Nrf2 in aging – focus on the cardiovascular system. Vasc Pharmacol, 2019, 112: 42-53.

Piechota-Polanczyk A., Kopacz A., Kloska D., Zagrapan B., Neumayer C., Grochot-Przeczek A., Huk I., Brostjan C., Dulak J., Jozkowicz A. 2018. Simvastatin treatment up-regulates HO-1 in patients with abdominal aortic aneurysm but independently of Nrf2. Oxid Med Cellular Longevity, 2018; 2028936.

Nowak W.N., Taha H., N. Kachamakova-Trojanowska N., Stepniewski J., Markiewicz J., Kusienicka A., Szade K., Szade A., Bukowska-Strakova K., Hajduk K., Klóska D., Kopacz A., Grochot-Przeczek A., Barthenheier K., Cauvin C., Dulak J., Jozkowicz A. Murine bone marrow mesenchymal stromal cells respond efficiently to oxidative stress despite the low level of heme oxygenases 1 and 2. Antioxid Redox Signal, 2018, 29: 111-127.

Bukowska-Strakova K., Szade K., Nowak W., Ciesla M., Straka R., Szade A., Tyszka-Czochara M., Najder K., Konturek A., Siedlar M., Dulak J., Jozkowicz A. Heme oxygenase 1 affects granulopoiesis in mice through control of myelocyte proliferation but not differentiation of granulocytic precursors. Immunobiology, 2017222: 506-517.

Kachamakova-Trojanowska N., Nowak W., Szade K., Stepniewski J., Bukowska-Strakova K., Zukowska M., Taha H., Chmura-Skirlinska A., Beilharz M., Dulak J., Jozkowicz A. Generation of functional endothelial cells with progenitor-like features from murine induced pluripotent stem cells. Vasc Pharmacol, 2016, 86: 94-108.

Ciesla M., Marona P., Kozakowska M., Jez M., Seczynska M., Loboda A., Bukowska-Strakova K., Szade A., Walawender M., Kusior M., Stępniewski J., Szade K., Krist B., Yagensky O., Urbanik A., Kazanowska B., Dulak J., Jozkowicz A. Heme oxygenase-1 controls an HDAC4-miR-206 pathway of oxidative stress in rhabdomyosarcoma. Cancer Res, 2016, 76: 5707-5718.

Szade K., Bukowska-Strakova K., Zukowska M., Jozkowicz A., Dulak J. Analysis of cell cycle status of murine hematopoietic stem cells. Methods Mol Biol, 2016, 1516: 91-99.

Szade K., Zukowska M., Szade A., Collet G., Kloska D., Jozkowicz A., Dulak J. Spheroid-plug model as a tool to study tumor development, angiogenesis and heterogeneity in vivo. Tumor Biol, 2016, 37: 2481-2496.

Szade K., Zukowska M., Jozkowicz A., Dulak J. Measuring ATP concentration in a small number of murine hematopoietic stem cells. Methods Mol Biol, 2016, 1516: 205-217.

Kotlinowski J., Jozkowicz A. PPARγ and angiogenesis – endothelial cell perspective. J Diabet Res, 2016: 8492353.

Szade A., Grochot-Przeczek A., Florczyk U., Jozkowicz A., Dulak J. Cellular and molecular mechanisms of inflammation-induced angiogenesis. IUBMB Life 2015, 67: 145-159.

Kozakowska M., Kotlinowski J., Grochot-Przęczek A., Ciesla M., Pilecki B., Derlacz R., Dulak J., Jozkowicz A. 2015. Myoblast-conditioned media improve regeneration and revascularization of ischemic muscles in diabetic mice. Stem Cell Res Ther, 6: 61.

Szade A., Nowak W., Szade K., Gese A., Czypicki R., Was H. Dulak J., Jozkowicz A. Effect of crossing C57BL6 and FVB mouse strains on basal cytokine expression. Mediators Inflammat, 2015: 762419.

Kotlinowski J., Grochot-Przeczek A., Taha H., Kozakowska M., Pilecki B., Skrzypek K., Bartelik A., Derlacz R., Horrevoets A.J.G., Pup A., Nagy L., Dulak J., Jozkowicz A. PPARγ activation but not PPARγ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors. Cardiovasc Diabetol, 2014, 13: 150-169.

Grochot-Przeczek A., Kotlinowski J., Kozakowska M., Starowicz K., Jagodzinska J., Stachurska A., Volger O.L., Bukowska-Strakova K., Florczyk U., Tertil M., Jazwa A., Szade K., Stepniewski J., Loboda A., Horrevoets A.J.G., Dulak J., Jozkowicz A. Heme oxygenase-1 is required for angiogenic function of the bone marrow-derived progenitor cells: role in therapeutic revascularization. Antioxid Redox Signal, 2014, 20: 1677-1992.

Nowak W.N., Borys S., Kusinska K., Bukowska-Strakova K., Witek P., Koblik T., Jozkowicz A., Malecki M.T., Dulak J. Number of circulating cells, growth factor and antioxidative gene profiles may be altered in type-2 diabetes with and without diabetic foot syndrome. J Diabetes Invest, 2014, 5: 99-107.

Ciesla M., Dulak J., Jozkowicz A. MicroRNAs and epigenetic mechanisms of rhabdomyosarcoma development. Int J Biochem Cell Biol 2014, 53: 482-492.

Kozakowska M., Szade K., Dulak J., Jozkowicz A. Role of heme oxygenase-1 in postnatal differentiation of stem cells: a possible cross-talk within microRNAs. Antioxid Redox Signal, 2014, 20: 1827-1850.

Grochot-Przeczek A., Dulak J., Jozkowicz A. Therapeutic angiogenesis for revascularization in peripheral arthery disease. Gene. 2013, 525: 220-228.

Szade K., Bukowska-Strakova K., Nowak W., Szade A., Kachamakova-Trojanowska N., Zukowska M., Jozkowicz A., Dulak J. Murine bone marrow Lin- Sca-1+ CD45- very small embryonic-like (VSEL) cells are heterogeneous population lacking Oct-4A expression. PLoS One. 2013, 8: e63329.

Bartelik A., Ciesla M., Kotlinowski J., Bartelik S., Czaplicki D., Grochot-Przeczek A., Kurowski K., Koteja P.,  Dulak J., Jozkowicz A. Development of hyperglycemia and diabetes in captive Polish bank voles. Gen Comp Endocrinol. 2013, 183: 69-78.

Nowak W.N., Mika P., Nowobilski R., Kusinska K., Bukowska-Strakova K., Nizankowski R., Jozkowicz A., Szczeklik A., Dulak J. Exercise training in intermittent claudication: effects on antioxidant genes inflammatory mediators, and proangiogenic progenitor cells. Thromb Haemos. 2012, 108: 824-831.

Grochot-Przęczek A., Dulak J., Jozkowicz A. Heme oxygenase-1: non-canonical roles in physiology and pathology. Clin Sci 2012, 122: 93-103.

Kozakowska M., Ciesla M., Stefanska A., Skrzypek K, Was H, Jazwa A, Grochot-Przeczek A, Kotlinowski J,Szymula A, Sierpniowska A, Mazan M., Yagensky O., Florczyk U., Lemke K., Zebzda A., Dyduch G., NowakW., Majka M., Derlacz R., Loboda A., Dulak J., Jozkowicz A. Heme oxygenase-1 inhibits myoblast differentiation by targeting myomirs. Antioxid Redox Signal. 2012, 16: 113-127.

Was H., Sokolowska M., Sierpniowska A., Dominik P., Skrzypek K., Lackowska B., Pratnicki A., Grochot-Przeczek A., Taha H., Kotlinowski J., Kozakowska M., Mazan A., Nowak W., Muchova L., Vitek L., Ratajska A., Dulak J., Jozkowicz J. Effect of heme oxygenase-1 on induction and development of chemically-induced squamous cell carcinoma in mice. Free Radic Mol Biol. 2011, 51: 1717-1726.

Taha H., Skrzypek K., Guevara I., Nigisch A., Mustafa S., Grochot-Przeczek A., Ferdek P., Was H., KotlinowskiJ., Kozakowska M., Balcerczyk A., Muchova L., Vitek L., Weigel G., Dulak J., Jozkowicz A. Role of heme oxygenase-1 in human endothelial cells – lesson from the promoter allelic variants. Arterioscler Thromb Vasc Biol 2010, 30: 1634-1641.

Was H., Dulak J., Jozkowicz A. Heme oxygenase in tumor biology and therapy. Current Drug Targets 2010, 11: 1551-1570.

Grochot-Przeczek A., Dulak J., Jozkowicz A. Heme oxygenase-1 in neovascularization: a diabetic perspective. Thromb Haemos, 2010, 104: 424-431.

Taha H., Grochot-Przeczek A., Was H., Kotlinowski J., Kozakowska M., Marek A., Skrzypek K., Lackowska B., Balcerczyk A., Mustafa S., Dulak J., Jozkowicz A. Modulation of inflammatory response bypentoxifylline is independent of heme oxygenase-1 pathway. J Physiol Pharmacol 2009, 60: 3-12.

Grochot-Przeczek A., Lach R., Mis J., Skrzypek K., Gozdecka M., Sroczynska P., Dubiel M., Rutkowski A., Kozakowska M., Zagorska A., Walczynski J., Was H., Kotlinowski J., Drukala J., Kurowski K., Kieda C., Herault Y., Dulak J., Jozkowicz A. Heme oxygenase-1 accelerates cutaneous wound healing in micePLoS One 2009, 4: e5803.

Jozkowicz A., Was H., Taha H., Kotlinowski J., Mleczko K., Cisowski J., Weigel G., Dulak J. 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress. Antioxidant Redox Signal 2008, 10: 2035-2046.

Deshane J., Chen S., Caballero S., Grochot-Przeczek A., Was H., Lach R., Hill-Kapturczak N., Siegal G.P., Dulak J., Jozkowicz A., Grant M.B., Agarwal A. Stromal cell-derived factor-1 promotes angiogenesis via heme oxygenase-1 dependent mechanism. J Exp Med, 2007, 204: 605-618.

Jozkowicz A., Waś H., Dulak J. Heme oxygenase-1 in tumors: is it a false friend? Antioxidant Redox Signal 2007, 9: 2099-2018.

Was H., Cichon T., Smolarczyk R., Rudnicka D., Stopa M., Chevalier C., Leger J.J., Lackowska B., Grochot A.,Bojkowska K., Ratajska A., Kieda C., Szala S., Dulak J., Jozkowicz A. Overexpression of hemeoxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice. Am J Pathol 2006, 169: 2181-2198.

Funovics P., Brostjan C., Nigisch A., Fila A., Grochot A., Mleczko K., Was H., Weigel G., Dulak J., JozkowiczA. 2006. Effects of 15d-PGJ2 on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. Prostaglandin Other Lipid Mediat 79: 230-244.

Dulak J., Schwartzacher SP, Zwick RH, Alber H., Millonig G., Weiss C., Hugel H., Frick M., Jozkowicz A., Pachinger O., Weidinger F. 2005. Effects of local gene transfer of VEGF-A on neointima formation after balloon injury in hypercholesterolemic rabbits. Vasc Med, 10: 285-291.

Józkowicz A., Dulak J. 2005. Helper-dependent adenoviral vectors in experimental gene therapy. Acta Biochim Pol, 326: 670-676.

Józkowicz A., Nigisch A., Winter B., Weigel G., Huk I., Dulak J. 2004. 15-deoxy-delta 12,14 -prostaglandin-J2 inhibitsexpression of eNOS in human endothelial cells. Prostaglandin Other Lipid Mediat 74: 11-28.

Józkowicz A., Nigisch A., Węgrzyn J., Weigel G., Huk I., Dulak J. 2004. Opposite effects of prostaglandin-J2 onVEGF in normoxia and hypoxia: role of HIF-1. Biochim Biophys Res Commun 314: 31-38.

Dulak J., Łoboda A., Zagórska A., Józkowicz A. 2004. Complex role of heme oxygenase-1 in angiogenesis. Antioxidant Redox Signal 6: 868-866.

Dulak J., Józkowicz A. 2003. Regulation of vascular endothelial growth factor synthesis by nitric oxide: facts and controversies. Antioxidant Redox Signal 5: 123-132.

Józkowicz A., Huk I., Nigisch A., Weigel G., Dietrich W., Motterlini R., Dulak J. 2003. Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide, inhibition by tin protoporphyrin-IX. Antioxidant Redox Signal 5: 155-162.

Józkowicz A., Huk I., Nigisch A., Weigel G., Weidinger F., Dulak J. 2002. Effect of prostaglandin-J2 on VEGF synthesis depends on the induction of heme oxygenase-1. Antioxidant Redox Signal 4: 577-585.

Kim I.H., Józkowicz A., Piedra P.A., Oka K., Chan L. 2001. Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci USA 98: 13282-13287.

Józkowicz A., Dulak J., Nigisch A., Winter B., Weigel G., Nanobashwili J., Prager M., Huk I. 2001. Prostaglandin-J2 induces the synthesis of interleukin-8 by endothelial cells in a PPARg-independent manner. Prostaglandins Other Lipid Mediat 66: 165-177.

Józkowicz A., Cooke J.P., Guevara I., Huk I., Funovics P., Pachinger O., Weidinger F., Dulak J. 2001. Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF. Cardiovasc Res 51: 773-783.

Józkowicz A., Dulak J., Piatkowska E., Placha W., Dembińska-Kieć A. 2000. Ligands of peroxisome proliferator-activated receptor-γ increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages. Acta Biochem Pol 47: 1147-1157.

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