Our current grants

Endothelial cells in the composition of hematopoietic niche: the versatile choir or specialized soloists?

Maestro program. National Science Centre. 
PI – Alicja Jozkowicz (to be completed in 2024).

Protein S-nitrosation as a trigger for DNA leakage from the nucleus: in the quest for a mechanism.

Preludium program. National Science Centre. 
PI – Aleksandra Kopacz (to be completed in 2023).

Heme metabolism in blood vessel wall - the influence on abdominal aortic aneurysm formation.

Sonata program. National Science Centre. 
PI – Witold Nowak (to be completed in 2023).

Cellular and molecular mechanisms driving the expression of mobilizing cytokines

Sonata program. National Science Centre. 
PI – Agata Szade (to be completed in 2023).

Senescence or apoptosis – the role of miR-34a in endothelial cells.

Sonata Bis Program. National Science Centre.

PI – Anna Grochot-Przęczek (to be completed in 2022).

Tracing the roots of leukemia - how pre-leukemic hematopoietic stem cells contribute to acute lymphoid and myeloid leukemias?

Harmonia Program (partner: prof. Irving L. Weissman, Stanford University). National Science Centre.

PI - Krzysztof Szade (to be completed in 2022).

Heme and G-quadruplexes: an overlooked function of heme oxygenases?

Opus Program. National Science Centre.  

PI – Alicja Jozkowicz.  (to be completed in 2021).

Induction of endogenous G-CSF for mobilization of hematopoietic stem cells for transplantation.

DKMS Foundation.

PI – Agata Szade (to be completed in 2021).

DNA repair in hematopoietic stem cells: what is a role of nuclear heme oxygenase-1?

Harmonia Program (partner: prof. Irving L. Weissman, Stanford University). National Science Centre.

PI – Alicja Jozkowicz  (to be completed in 2020).

Aging of hematopoetic stem cells - unrevealed role of Neogenin-1/Netrin-1 axis.

HOMING program. The Foundation for Polish Science.

PI - Krzysztof Szade (to be completed in 2020).

All hands on deck”: the interdisciplinary approach against pancreatic cancer and its fibrotic stroma.

HOMING program (partner: PI - Paweł Ferdek, FBBB). The Foundation for Polish Science.

PI - Monika Jakubowska; MCB (to be completed in 2020).

Characterization of hematopoietic stem cell subpopulations with accelerated cell cycle – role of Neo-1 and HO-1.
Etiuda Program. National Science Centre.  

PI - Monika Żukowska. (to be completed in 2020).

Molecular mechanism of new apoptosis induction strategy in the experimental anticancer targeted therapy.

Etiuda Program. National Science Centre.  

PI - Damian Klóska. (to be completed in 2020).

Role of heme oxygenase-1 in melanoma initiating cells and melanogenesis.

Etiuda Program. National Science Centre.  

PI - Anna Kusienicka. (to be completed in 2020).

Targeting mechanisms of pancreatic cancer resistance against therapy: specific role of tumour microenvironment.

HOMING program. The Foundation for Polish Science.

PI - Monika Jakubowska; MCB. (to be completed in 2019).

Completed grants

  • Molecular mechanism of GDF-15 and SDF-1-induced angiogenesis – non-canonical role of Nrf2 transcription factor. Opus Program. National Science Centre. PI – Anna Grochot-Przęczek (completed in 2017) 

  • The role of Nrf2 in angiogenesis induced by GDF-15 and SDF-1 in vivo. Iuventus Plus Program. Ministry of Science and Higher Education. PI – Anna Grochot-Przęczek (completed in 2017) 

  • Heme oxygenase-1 and progression of melanoma: role in cancer initiating cellsHarmonia Program (partner: prof. Claudine Kieda, CNRS Orleans). National Science Centre. PI – Alicja Jozkowicz (completed in 2016) 

  • Endothelium in pathogenesis and therapy of modern-age diseases: from basic science to innovative endothelium-targeted drug". National Centre for Research and Development. Research task suprervisor – Alicja Jozkowicz (completed in 2015) 

  • Effect of heme oxygenase-1 on differentation of satellite cells: role of miRNA. National Science Centre. PhD student project for dr. Magdalena Kozakowska, PI – Alicja Jozkowicz (completed in 2012) 

  • Effect of reduced expression of PPARγ on function of endothelial progenitor cells in diabetes. National Science Centre. PhD student project for dr Jerzy Kotlinowski, PI – Alicja Jozkowicz (completed in 2012). 

  • Endothelial progenitor cells in therapy of ischemic hind limb in diabetic mice – role of oxygenase-1. National Science Centre. PhD student project for dr. Anna Grochot-Przeczek, PI – Alicja Jozkowicz (completed in 2012)

  • Molecular Biotechnology for Health. POIG. National Centre for Research and Development. Research task coordinator – Alicja Jozkowicz (completed in 2012)

  • Jagiellonian Centre for Experimental Therapeutics. POIG. National Centre for Research and Development. Research task coordinator – Alicja Jozkowicz (completed in 2012)

  • Role of HO-1 in induction and progression of esophageal carcinoma. National Science Centre. PI – Alicja Jozkowicz (completed in 2012)

  • The role of HO-1 translocation to the nucleus in the squamous cancer cellsFaculty of Biochemistry, Biophysics and Biotechnology. Research projects for young researchers and PhD students. PI – Agata Szade (completed in 2012)

  • Role of HO-1 in satellite cellsADAMED Ltd. PhD student project for dr. Magdalena Kozakowska, PI – Alicja Jozkowicz (completed in 2011)

  • Effect of diabetes and major antidiabetic drugs on endothelial progenitor cells. ADAMED Ltd. PhD student project for dr Jerzy Kotlinowski, PI – Alicja Jozkowicz (completed in 2011)

  • Cytoprotective and proangiogenic gene therapy for critical limb ischemia in diabetic mice. Sunset Award. The Wellcome Trust. PI – Alicja Jozkowicz (completed in 2011)

  • Protective role of HO-1 in endothelial cells – construction of helper-dependent adenoviral vectors for a long term heme oxygenase expression. An International Senior Research Fellowship in Biomedical Science. The Wellcome Trust. PI – Alicja Jozkowicz (completed in 2010)

  • Role of HO-1 in stroma cells on development of melanoma. Ministry of Science and Higher Education. PhD student project for dr. Halina Was, PI – Alicja Jozkowicz (completed in 2009)

  • Polish innovative drug in therapy of diabetes based on the activation of PPARγ – preclinical studies. European Funds for Structural Development. Research task supervisor - Alicja Jozkowicz (completed in 2008)

  • Construction of gutless adenoviral vectors – effect of HO-1 on the wound healing. Ministry of Science and Higher Education. PI – Alicja Jozkowicz (completed in 2007)

  • Role of HO-1 in cytoprotective and anti-inflammatory effects of pentoxifylline. Ministry of Science and Higher Education. Research task supervisor – Alicja Jozkowicz (completed in 2007)

  • Role of peroxisome proliferator activated receptors-γ (PPARg) in angiogenesis. Ministry of Science and Higher Education. PI – Alicja Jozkowicz (completed in 2002)

  • Mechanisms of rejection of allogenic and xenogenic skin grafts in anuran amphibians. Ministry of Science and Higher Education. PI – Alicja Jozkowicz (completed in 1995)

  • Czarny Instagram Ikona

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