Our current grants
Aging of hematopoetic stem cells - unrevealed role of Neogenin-1/Netrin-1 axis.
HOMING program. The Foundation for Polish Science.
PI - Krzysztof Szade (to be completed in 2020).
Hematopoietic stem cells (HSCs) sustain production of all blood cells through the lifetime. However,
HSCs gradually lose their regenerative potential during aging. The project will check whether bone
marrow (BM) niche drives age-related disturbances among HSCs. Proposed experiments will verify
if the changes in the niche acquired during aging contribute to decline in function of HSC in elderly
individuals. We will verify the possible mechanism of HSC-niche interactions during aging. Our
preliminary data suggests that Neogenin-1 (Neo-1)/Netrin-1 (Ntn-1) axis may be implicated in
niche-driven aging of HSC. To verify our hypothesis we proposed approach based on new
transgenic mouse models. Finally, we check whether Neo-1 defines the aging fraction of human
HSCs and whether Ntn-1 is conserved among human BM niche. The project will contribute to
understanding how bone-marrow niche regulates aging of HSCs and how this knowledge can be
translated to clinical application.