Our paper published in EMBO Mol Med!
Our article Cobalt protoporphyrin IX increases endogenous G‐CSF and mobilizes HSC and granulocytes to the blood was published in EMBO Molecular Medicine.
Mobilization of cells from the bone marrow to the blood using recombinant G-CSF is the most often used therapy for the treatment of neutropenia or harvesting hematopoietic stem cells (HSC) for transplantation. We show that cobalt protoporphyrin IX (CoPP) increases endogenous G -CSF expression and induces mobilization.
Compared to recombinant G-CSF, CoPP mobilizes granulocytes with more mature phenotype, and higher number of functional HSC.
The full version of the article is available at EMBO Mol Med website: https://www.embopress.org/doi/10.15252/emmm.201809571