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  • witoldnowak1

When good guys make trouble...

We are happy to share with you our recent publication!


Co-administration of angiotensin II and simvastatin triggers kidney injury upon heme oxygenase-1 deficiency

Kopacz A, Klóska D, Cysewski D, Kraszewska I, Przepiórska K, Lenartowicz M, Łoboda A, Grochot-Przęczek A, Nowak W, Józkowicz A, Piechota-Polańczyk A. Free Radic Biol Med. 2023, S0891-5849(23)00434-3.


doi: 10.1016/j.freeradbiomed.2023.05.018.


We show that simvastatin and angiotensin II damage kidneys of heme oxygenase-1 deficient (Hmox1 KO) mice. Interestingly, Hmox1 KO mice respond to oxidative stress with upregulation of glutathione pathway.


Read more here:

https://www.sciencedirect.com/science/article/pii/S0891584923004343




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