We published in PNAS our work demonstrating that Neogenin-1 (Neo-1) marks myeloid-biased fraction of Hoxb5+ hematopoietic stem cells (HSCs) in mouse.
The Neo-1+Hoxb5+HSCs expanded with age, but provided limited reconstitution of secondary recipients. In contrast, Neo-1-Hoxb5+ HSCs subpopulation represents balanced, long-term reconstituting fraction of stem cells.
Importantly the Neo-1- fraction gives rise to Neo-1+ HSC, but the opposite situation is rare.
Our work shows unknown layer of HSCs heterogeneity and allows for advanced and
prospective studies of HSCs .
This study was done during Krzysiek and Monika training in Irv Weissman laboratory.
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