• witoldnowak1

The good Hmox1, the bad Hmox1 and the ugly... abdominal aortic aneurysm

One in one hundred men over 60 years old will develop abdominal aortic aneurysm (AAA), and only 15-35% of people survive the aneurysm rupture. Aleksandra Piechota-Polańczyk and co-workers showed recently that Hmox1-deficient mice are protected from the formation of angiotensin II-induced abdominal aortic aneurysm. On the other hand, if they do develop AAA, they are significantly more prone to rupture.


You can find more here:


Kopacz A, Klóska D, Werner E, Hajduk K, Grochot-Przęczek A, Józkowicz A, Piechota-Polańczyk A. A Dual Role of Heme Oxygenase-1 in Angiotensin II-Induced Abdominal Aortic Aneurysm in the Normolipidemic Mice. Cells. 2021; 10(1):163.


https://www.mdpi.com/2073-4409/10/1/163




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