One in one hundred men over 60 years old will develop abdominal aortic aneurysm (AAA), and only 15-35% of people survive the aneurysm rupture. Aleksandra Piechota-Polańczyk and co-workers showed recently that Hmox1-deficient mice are protected from the formation of angiotensin II-induced abdominal aortic aneurysm. On the other hand, if they do develop AAA, they are significantly more prone to rupture.
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Kopacz A, Klóska D, Werner E, Hajduk K, Grochot-Przęczek A, Józkowicz A, Piechota-Polańczyk A. A Dual Role of Heme Oxygenase-1 in Angiotensin II-Induced Abdominal Aortic Aneurysm in the Normolipidemic Mice. Cells. 2021; 10(1):163.
